TITLE:
Serum Magnesium Levels in Healthy Pregnant and Pre-Eclamptic Patients —A Cross-Section Study
AUTHORS:
D. A. Adekanle, O. T. Adeyemo, A. A. Adeniyi, R. A. Okere, A. K. Jimoh, I. O. Adebara, A. Bakare, A. S. Atiba, A. Adelekan, B. A. Olofinbiyi
KEYWORDS:
Pre-Eclampsia, Eclampsia, Serum Magnesium, Marker and Prophylaxis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.9,
June
26,
2014
ABSTRACT: Background: Pre-eclampsia
complicates 2% - 8% of pregnancies. Various efforts have been put forward for
its prevention and treatment. Magnesium sulphate is presently the recommended
drug for the prevention and treatment of eclampsia and severe pre-eclampsia.
Objectives: The study aimed to compare the serum magnesium in a healthy
pregnant women and pre-eclamptic women. It determined demographic characteristic
of the study population and recommended the prophylactic usage of magnesium
sulphate in pregnancy in our environment. Method: This was a prospective case
control study comparing the serum magnesium levels in pre-eclampsia and normal
pregnancy tertiary hospitals. The women who satisfied the inclusion criteria
were recruited in the two groups (seventy five in the healthy pregnant women
and seventy five in the pre-eclamptic women). The blood samples were collected
and analysed for the serum magnesium and urine sample for urinalysis. Result:
Total of 150 patients comprises 75 normal pregnant women and 75 cases of
pre-eclampsia. The mean serum magnesium in the normal pregnant women was 0.73
(±0.14) mmol/L while in preeclampsia the level was 0.58 (±0.17) mmol/L. This is
statistically significant (t = 6.120, p = 0.000). There was significance
difference in the mean age of patients with pre-eclampsia and normal pregnancy.
The mean parity in the pre-eclampsia was 0.80 and in the normal pregnancy was
1.4 and was statistically significant (t = 3.40, p value