TITLE:
Prognostic Value of Neutrophil Lymphocyte Ratio in Second Line Advanced Malignant Pleural Mesothelioma
AUTHORS:
Ahmed El Bastawisy, Maha Yahia, Abdel Rahman M. Abdel Rahman, Rabab Gaafar
KEYWORDS:
Neutrophil Lymphocyte Ratio, Mesothelioma
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.7,
June
23,
2014
ABSTRACT: Background:
Malignant pleural mesothelioma is a lethal disease and hence the strong need for
identifying new prognostic factors. Methods: This is a retrospective study
including all eligible patients with advanced malignant pleural mesothelioma
(MPM) presenting to National Cancer Institute, Cairo University. Neutrophil
lymphocyte (N/L) ratio was assessed before second line chemotherapy. 2.5 was
used as the cutoff point. Endpoints were the assessment of correlation between
N/L ratio and clinical response (CR), progression free survival (PFS) and
overall survival (OS). Results: 52 patients (19 stage III and 33 stage IV) MPM
were included and followed up during the period from July 2009 till November
2012 with a median follow-up period of 2.6 months. 87.5% of patients with N/L
ratio > 2.5 showed progressive disease versus 91.7% in patients with N/L
ratio 2.5 versus 14% for patients with N/L ratio 2.5 versus 66% for patients
with N/L ratio