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Saito, M., Schetter, A.J., Mollerup, S., Kohno, T., Skaug, V., Bowman, E.D., Mathé, E.A., Takenoshita, S., Yokota, J., Haugen, A. and Harris, C.C. (2011) The Association of microRNA Expression with Prognosis and Progression in Early-Stage, Non-Small Celllung Adenocarcinoma: A Retrospective Analysis of Three Cohorts. Clinical Cancer Research, 17, 1875-1882. http://dx.doi.org/10.1158/1078-0432.CCR-10-2961

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• TITLE: Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer

  AUTHORS: Laura Boldrini, Mirella Giordano, Adele Servadio, Greta Alì, Alice Cocco, Marco Lucchi, Pietro Bertoglio, Franca Melfi, Alfredo Mussi, Gabriella Fontanini

  KEYWORDS: Non-Small Cell Lung Cancer, miR-21, let-7g, miR-205, Prognosis

  JOURNAL NAME: Advances in Lung Cancer, Vol.3 No.2, June 20, 2014

  ABSTRACT: Background: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of miRNA let-7, miR-21, and miR-205 are inconclusive. The aim of the present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAsin early-stage(T1N0) NSCLC patients. Methods: Quantification of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage NSCLC by quantitative Real Time-PCR (qRT-PCR).Results: a significant association between the low miR-205 expression and ADC histotype (p0.0001) compared to SCCwas found; moreover, survival analysis showed thattumors with a highmiR-205 expression had a significantly shorter mean PFS and OS compared to the patients with a low expression of this miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant correlations were observed between the analysed miRNAs and the main clinico-pathological characteristics of the NSCLC patients. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients.