TITLE:
Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer
AUTHORS:
Laura Boldrini, Mirella Giordano, Adele Servadio, Greta Alì, Alice Cocco, Marco Lucchi, Pietro Bertoglio, Franca Melfi, Alfredo Mussi, Gabriella Fontanini
KEYWORDS:
Non-Small Cell Lung Cancer, miR-21, let-7g, miR-205, Prognosis
JOURNAL NAME:
Advances in Lung Cancer,
Vol.3 No.2,
June
20,
2014
ABSTRACT: Background: Published data have shown
that microRNAs (miRNAs) could play a potential role as diagnostic and
prognostic indicators in cancers. Data for the predictive value of miRNA let-7,
miR-21, and miR-205 are inconclusive. The aim of the present analysis was
therefore to evaluate the expression and the prognostic role of the above
mentioned miRNAsin early-stage(T1N0) NSCLC patients. Methods: Quantification
of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage
NSCLC by quantitative Real Time-PCR (qRT-PCR).Results: a significant association
between the low miR-205 expression and ADC histotype (p0.0001) compared to SCCwas
found; moreover, survival analysis showed thattumors with a highmiR-205 expression had a significantly
shorter mean PFS and OS compared to the patients with a low expression of this
miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant
correlations were observed between the analysed miRNAs and the main
clinico-pathological characteristics of the NSCLC patients. Conclusion: The
results indicated that miR-205 could represent a useful marker in the
prognostic management of the early-stage (T1N0) NSCLC patients.