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Ambros, V., Bartel, B., Bartel, D.P., Burge, C.B., Carrington, J.C., Chen, X., Dreyfuss, G., Eddy, S.R., Griffiths-Jones, S., Marshall, M., Matzke, M., Ruvkun, G. and Tuschl, T. (2003) A Uniform System for MicroRNA Annotation. RNA, 9, 277-279. http://dx.doi.org/10.1261/rna.2183803

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• TITLE: Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer

  AUTHORS: Laura Boldrini, Mirella Giordano, Adele Servadio, Greta Alì, Alice Cocco, Marco Lucchi, Pietro Bertoglio, Franca Melfi, Alfredo Mussi, Gabriella Fontanini

  KEYWORDS: Non-Small Cell Lung Cancer, miR-21, let-7g, miR-205, Prognosis

  JOURNAL NAME: Advances in Lung Cancer, Vol.3 No.2, June 20, 2014

  ABSTRACT: Background: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of miRNA let-7, miR-21, and miR-205 are inconclusive. The aim of the present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAsin early-stage(T1N0) NSCLC patients. Methods: Quantification of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage NSCLC by quantitative Real Time-PCR (qRT-PCR).Results: a significant association between the low miR-205 expression and ADC histotype (p0.0001) compared to SCCwas found; moreover, survival analysis showed thattumors with a highmiR-205 expression had a significantly shorter mean PFS and OS compared to the patients with a low expression of this miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant correlations were observed between the analysed miRNAs and the main clinico-pathological characteristics of the NSCLC patients. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients.