TITLE:
An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water
AUTHORS:
Kishor S. Jain, Jitender B. Bariwal, Muthu K. Kathiravan, Vikas K. Raskar, Gajanan S. Wankhede, Nitin A. Londhe, Satish N. Dighe
KEYWORDS:
Green Chemical Synthesis, MWI, Water, 2-amino-4-arylthiazoles
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.2,
May
3,
2011
ABSTRACT: A facile, high yielding green chemical synthetic protocol adaptable to the parallel synthesis of a library of potentially bioactive 2-amino-4-arylthiazoles is reported herein. The methodology involves the condensation of various aracyl bromides with N-arylthioureas under MWI using water as solvent, to yield pure products (81%-97%) in very short reaction times (1-20 min).