TITLE:
Human Amniotic Allograft in Use on Talar Dome Lesions: A Prospective Report of 37 Patients
AUTHORS:
John Joseph Anderson, Zflan Swayzee, Myron Holbert Hansen
KEYWORDS:
Bone Lesions, Human Amniotic Allograft, Ankle Arthroscopy, Talus Fractures, Cartilage Restoration, Stem Cells
JOURNAL NAME:
Stem Cell Discovery,
Vol.4 No.3,
June
19,
2014
ABSTRACT: One of the most
challenging joint conditions facing ankle surgeons today is the treatment of Osteochondritis
Dissecans (OCD) of the talar dome. The use of human amniotic allograft (HAA) in
various surgical procedures, has been proven to facilitate bone growth and both
soft tissue and cartilage healing. The authors of this paper propose the
addition of HAA to the surgical repair of talar dome lesions to improve
postoperative results, specifically pain reduction. For the study, 37 patients
were identified having an OCD lesion of the talus measuring no larger than 2 cm2.
All patients were treated surgically with an arthroscopic micro-fracture repair
along with the addition of HHA. Modified ACFAS ankle scores were taken
pre-operatively and at 3 months, 12 months, and at 24 months postoperatively.
Visual analog scores were also taken preoperative and 24 months
postoperatively. The size of the talar lesions documented with pre-operative
MRI’s was compared with intra-operative measurements for each patient.
Additional surgical repairs, comorbidities and any complications were also
recorded and evaluated. All patients were treated with micro-fracture with HAA.
Postoperative ACFAS scores for 3 months, 12 months and 24 months were
significantly improved (p 2has shown to significantly improve
both post-operative VAS scores, when compared to preoperative scores. This
improvement in ACFAS and VAS scores speaks to the potential use of HAA in the
treatment of OCD.