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J. W. Baum, J. T. Bamberg and J. A. Grina, Sandoz Ltd, PCT Int Appl WO 95 19,358, 20 Jul. 1995, “Preparation of Herbicidal Aryl and (Hetero) Arylpyrimidines,” Chemical Abstracts, Vol. 123, 1995, p. 340179k.

has been cited by the following article:

• TITLE: Synthesis of Novel Bis-enaminones by KHSO4-assisted Facile Michael Addition-elimination Reaction of 3-(dimethylamino)-1-phenylprop-2-en-1-ones with Diamines in Water

  AUTHORS: Asem Satyapati Devi, Philippe Helissey, Jai Narain Vishwakarma

  KEYWORDS: Enaminone, Bis-enaminone, Formylated Acetophenone, Michael Addition-Elimination, Formylation, Dimethylformamide-dimethylacetal

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.1 No.2, April 13, 2011

  ABSTRACT: 3-(Dimethylamino)-1-phenylprop-2-en-1-ones (formylated acetophenones) 1 reacted with aliphatic diamines in water assisted by KHSO4 to give bis-enaminones 2a-h in good yields. Compound 1 also reacted with o-phenylenediamine under similar conditions to produce bis-enaminones 3 instead of benzodiazepines 4 in excellent yields.