TITLE:
Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion
AUTHORS:
Blanca Estela Jaramillo, Fidel De la Cruz, Genaro Vargas, Oscar O. Morales, Gonzalo Flores, Sergio R. Zamudio, Linda Garcés-Ramírez
KEYWORDS:
Immobility Response, Sigma Receptor, DTG, Schizophrenia, Neonatal Ventral Hippocampal Lesion
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.7,
June
17,
2014
ABSTRACT: The effect of chronic administration of the sigma agonist: 1,3-di-o-tolyl-guanidine
(DTG), in neonatal ventral hippocampal lesioned (nVHL) rats, on the
immobility by clamping and dorsal immobility, were investigated. The nVHL
increases the duration of immobility by clamping, but does not affect the
duration of the dorsal immobility. We found that DTG augments the duration of
the dorsal immobility in the unlesioned rats, but does not modify the duration
of immobility induced by clamping the neck. DTG also counteracts the increase
in the duration of the immobility by clamping produced by nVHL. However, the
increase in the duration of the dorsal immobility produced by DTG is
counteracted by nVHL. These results are discussed with respect to the
differential effect on the two immobility responses tested, suggesting that
they are different forms of immobility mediated by different mechanisms
although they behaviorally share common characteristics.