TITLE:
Detection of Hypoglycemic and Antidiabetic Fraction in Ethanol Extract of Jatropha curcas Aerial Parts
AUTHORS:
Mohamed Farag, Adnan Al-Rehaily, Mohammad Shamim Ahmad, Ramzi Ahmed Mothana
KEYWORDS:
Herbal Medicine, Jatropha curcas, Hypoglycemic Effect, Antidiabetic Effect, Active Fraction
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.7,
June
17,
2014
ABSTRACT: Diabetes is a global problem and many efforts are being done all over the
world searching for new drugs that can manage it more efficiently. The World
Health Organization recommended the natural products to be possible source for
antidiabetic compounds. Jatropha curcas plant was employed in Indian
traditional medicine for the treatment of several disorders. So, hexane, chloroform
and ethanolic extracts of the aerial part were subjected for evaluation of
their hypoglycemic and antidiabetic effects. Oral administration of ethanolic
extract at a dose of 400 mg/kg showed hypoglycemic and antidiabetic activities
in alloxan induced diabetic mice. Bioassay-guided fractionation used to isolate
the active fraction. Moreover, the drug was found to be safe up to dose of 5
g/kg. Further fractionation is recommended to find the active compound(s).