TITLE:
Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice
AUTHORS:
Mahsa Hadipour Jahromy, Golnar Golbaghi, Ahmad Jamshidi Mohajer, Fatemeh Kamali Poor, Mahdieh Riazi
KEYWORDS:
Anxiety, Magnesium Chloride, Buspirone, Mice
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.7,
June
17,
2014
ABSTRACT: Anxiolytic-like
activity of magnesium chloride has been exhibited in the elevated plus-maze
test in mice, in several studies. Buspirone is an anxiolytic psychoactive drug
of the azapirone chemical class that is not related to benzodiazepines, unlike
most drugs predominately used. The purpose of the present study was to examine
interaction between magnesium (Mg) and buspirone as a partial agonist of 5-HT1A receptors in producing anxiolytic-like activity in the elevated plus maze. The
anxiolytic-like effect of Mg (50, 100 and 200 mg/kg, orally), buspirone (5 mg/kg,
i.p) and its interaction with Mg (50 mg/kg) was evaluated after ten days
treatment. Mg given at all doses (50, 100 and 200 mg/kg) and buspirone (5 mg/kg)
induced an anxiolytic-like effect significantly increasing the percentage of
the time spent in the open arms (%OAT), the percentage of the open arm entries
(%OAE) and number of total entries. Percent time spend in open arms was reduced
when buspirone coadministered with Mg (50 mg/kg) compared to Mg alone. However,
the number of entries did not change significantly. No synergistic interaction
(increased time in open arms and number of open arm entries) between Mg and
buspirone was observed, in this test, on the contrary, %OAT preserved about
buspirone effects and %OAE remained around Mg effect. The obtained data indicate
that Mg may act partly via serotonergic receptors due to buspirone’s inhibitory
action as a partial agonist of serotonin receptor.