TITLE:
Identification of Genetic Variants Underlying Anxiety and Multiple Sclerosis in Heterogeneous Stock Rats
AUTHORS:
Amelie Baud, Jonathan Flint, Alberto Fernandez-Teruel, The Rat Genome Sequencing Mapping Consortium
KEYWORDS:
Genetic Mapping, Imputation, Causal Variants, Anxiety, Multiple Sclerosis, Complex Traits
JOURNAL NAME:
World Journal of Neuroscience,
Vol.4 No.3,
June
10,
2014
ABSTRACT: Identifying genetic variants that contribute to phenotypic
variation is expected to provide insights into the etiology of complex
traits. Here we show how combining genetic mapping in an outbred population of
rats with sequence data from the progenitors of the population made it possible
to identify causal variants and genes for a large number of phenotypes. We
identified 355 genomic loci contributing to 122 measures
relevant to six models of disease, including fear-related behaviors and
experimental autoimmune encephalomyelitis. At 35 of those loci we identified the responsible gene, and in some
cases, the responsible variant.