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Veyrieras, J.B., Kudaravalli, S., Kim, S.Y., Dermitzakis, E.T., Gilad, Y., Stephens, M., et al. (2008) High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation. PLOS Genetics, 4, Article ID: e1000214.

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• TITLE: Identification of Genetic Variants Underlying Anxiety and Multiple Sclerosis in Heterogeneous Stock Rats

  AUTHORS: Amelie Baud, Jonathan Flint, Alberto Fernandez-Teruel, The Rat Genome Sequencing Mapping Consortium

  KEYWORDS: Genetic Mapping, Imputation, Causal Variants, Anxiety, Multiple Sclerosis, Complex Traits

  JOURNAL NAME: World Journal of Neuroscience, Vol.4 No.3, June 10, 2014

  ABSTRACT: Identifying genetic variants that contribute to phenotypic variation is expected to provide insights into the etiology of complex traits. Here we show how combining genetic mapping in an outbred population of rats with sequence data from the progenitors of the population made it possible to identify causal variants and genes for a large number of phenotypes. We identified 355 genomic loci contributing to 122 measures relevant to six models of disease, including fear-related behaviors and experimental autoimmune encephalomyelitis. At 35 of those loci we identified the responsible gene, and in some cases, the responsible variant.