Article citationsMore>>

D’Amico, D., Carbone, D., Mitsudomi, T., Nau, M., Fedorko, J., Russell, E., Johnson, B., Buchhagen, D., Bodner, S., Phelps, R., et al. (1992) High Frequency of Somatically Acquired p53 Mutations in Small-Cell Lung Cancer Cell Lines and Tumors. Oncogene, 7, 339-346.

has been cited by the following article:

• TITLE: Radiation-Induced Lung Cancers in Murine Models

  AUTHORS: Leena Rivina, Michael Davoren, Robert H. Schiestl

  KEYWORDS: Radiation Carcinogenesis, Animal Models, Radiation Protectors, Radiation Mitigators, Secondary Cancers

  JOURNAL NAME: Advances in Lung Cancer, Vol.3 No.2, June 16, 2014

  ABSTRACT: Radiation therapy is a key weapon in the modern arsenal of cancer treatment. However, this effective treatment comes with risks of its own, and the sheer number of patients that undergo radiation as a part of their therapy regimen is only increasing. As this number increases, so does the incidence of secondary, radiation-induced neoplasias, creating a need for therapeutic agents targeted specifically towards reduction in the incidence of and treatment of these cancers. Development and efficacy testing of these agents requires not only extensivein vitrotesting, but also a set of reliable animal models to accurately recreate the complex situations of radiation-induced carcinogenesis. The laboratory mouseMus musculusremains the most relevant animal model in cancer research due to the molecular and physiological similarities it shares with man, its small size and high rate of breeding in captivity, and its fully sequenced genome. In this work, we review relevantM. musculusinbred andF1hybrid animal models, as well as methods of induction of radiation-induced lung cancers. Associated molecular pathologies are also included.