TITLE:
Radiation-Induced Lung Cancers in Murine Models
AUTHORS:
Leena Rivina, Michael Davoren, Robert H. Schiestl
KEYWORDS:
Radiation Carcinogenesis, Animal Models, Radiation Protectors, Radiation Mitigators, Secondary Cancers
JOURNAL NAME:
Advances in Lung Cancer,
Vol.3 No.2,
June
16,
2014
ABSTRACT: Radiation therapy is a key
weapon in the modern arsenal of cancer treatment. However, this effective
treatment comes with risks of its own, and the sheer number of patients that
undergo radiation as a part of their therapy regimen is only increasing. As
this number increases, so does the incidence of secondary, radiation-induced
neoplasias, creating a need for therapeutic agents targeted specifically
towards reduction in the incidence of and treatment of these cancers. Development
and efficacy testing of these agents requires not only extensivein vitrotesting, but also a set of reliable
animal models to accurately recreate the complex situations of
radiation-induced carcinogenesis. The laboratory mouseMus musculusremains the most relevant animal model
in cancer research due to the molecular and physiological similarities it
shares with man, its small size and high rate of breeding in captivity, and its
fully sequenced genome. In this work, we review relevantM. musculusinbred andF1hybrid animal models, as well as
methods of induction of radiation-induced lung cancers. Associated molecular
pathologies are also included.