TITLE:
Dietary Magnesium Intake Related to C-Reactive Protein in Newly Diagnosed Coronary Heart Disease Patients at Middle Zone, Gaza Strip. A Hospital Based Study
AUTHORS:
Jehad H. El-Hissi, Adham I. Ahmed, Ihab M. Al-Masri, Mazen A. El-Sakka, Atef A. Masad, Ahmed A. Najem
KEYWORDS:
Coronary Heart Disease, C-Reactive Protein, Magnesium, Dietary Behavior, Life Style
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.7,
June
13,
2014
ABSTRACT: Coronary Heart
Disease (CHD) is a highly prevalent disease all over the world. Magnesium (Mg)
plays a role in CHD but it is still unclear. C-Reactive Protein (CRP) is an
inflammatory marker which may rise in CHD. Aim of study: To assess the impact
of dietary Mg intake and its level in relation to CRP among newly diagnosed
CHD at middle zone of Gaza Strip. Methodology: Patients (n = 140) with
confirmed CHD, 50 ± 10 years, presented in the cardiac care unit at Aqsa Martyr’s
Hospital between 1 April 2012 and 30 December 2012, were enrolled in this
cross-sectional study after taking consent. ECG, clinical status, and cardiac
markers were used to confirm diagnosis by cardiologist. Food frequency
questionnaire was used to assess Mg intake and calcium intake in addition to
measurement of its level in serum. CRP latex slide was used for measurement of
CRP. Results: Mg intake and serum Mg wereinversely associated with riskof
CHD. Mean of serum Mg among cases (1.80) was
lower than controls (2.41) (P =
0.001). Percent of positive CRP was higher in cases (32.9%) than
controls (12.9%) (P = 0.005). Mean of
serum Mg was (1.96 ± 0.47) for positive CRP which
was lower than the mean of serum Mg (2.15 ± 0.44) for negative CRP. Conclusion:
Newly diagnosed patients with CHD have a positive CRP, low serum and lowMg intake, and low serum Mg was associated with
elevated CRP.