TITLE:
Methicillin-Resistant Staphylococcus aureus SCCmec Type and Its Association with Clinical Presentation, Severity, and Length of Stay among Patients with Complicated Skin and Skin Structure Infections
AUTHORS:
Eric Gomez, Tom Chiang, Patricia A. Hogan, Daniela E. Myers, David B. Huang
KEYWORDS:
MRSA, SCCmec Type, Infection Severity, Length of Stay
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.4 No.2,
June
13,
2014
ABSTRACT: Data from a prospective, randomized,
open-label, active-controlled, multicenter, Phase 4 study comparing oral or
intravenous linezolid with intravenous vancomycin for treatment of complicated
skin and soft-tissue infections caused by methicillin resistant Staphylococcus
aureus was used to determine the association between staphylococcal cassette
chromosome mec (SCCmec) type and patient’s clinical presentation, infection
severity, intravenous therapy duration and length of stay (LOS). Compared to
SCCmec types I, II, and III, SCCmec type IV, PVL+ was associated with more
frequent presentation of abscesses, lower severity scores, and shorter
intravenous therapy duration and LOS in both treatment groups.