TITLE:
Roles of BMP6/7 in Actin Dynamics in Amyloid β-Induced Neurotoxicity
AUTHORS:
Lin Sun, Yingjie Zhang, Shifu Xiao
KEYWORDS:
Amyloid β, BMP, Actin Dynamics, LIMK1, Alzheimer’s Disease
JOURNAL NAME:
Psychology,
Vol.5 No.7,
May
22,
2014
ABSTRACT: Actin
dynamics plays an important role in many physiological functions such as
long-term potentiation, neurotransmission, regulatory proteins translocation, ATP
cycle, etc. When amyloid β (Aβ)-induced neurotoxicity occurs, the imbalance of
actin dynamics leads to dystrophy of dendrites, which is characteristic
pathology in Alzheimer’s disease (AD). Transient and persistent Aβ
neurotoxicity provokes distinct manifestations of actin dynamics and causes
opposing effects in AD. It has been shown that bone morphogenetic protein 6/7
(BMP6/7) protects neuronal morphology against Aβ-induced neurotoxicity, and can
directly bind to LIM kinase1 (LIMK1), being one part of the upstream regulatory
pathway of actin dynamics. This review aims to discuss a potential mechanism of
BMPs underlying maintainance of cytoskeletal stabilization in neurite.