TITLE:
Prevalence, Incidence and Risk Factors for Acquisition of Herpes Simplex Virus Type 2 among Fishermen on the Shores of Lake Victoria in Kisumu County, Kenya
AUTHORS:
Raphael O. Ondondo, Zipporah W. Ng’ang’a, Solomon Mpoke, Michael K. Kiptoo, Elizabeth A. Bukusi
KEYWORDS:
Fishermen, Risk Factors, HSV-2 Incidence, HSV-2 Prevalence, HPV, HIV
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.4 No.2,
June
9,
2014
ABSTRACT: Background: Herpes simplex virus Type 2 (HSV-2) has
been associated with HIV infection. More recently, HSV-2 incidence has been
linked to HIV acquisition. A few studies have suggested that the fishing
communities have a high HSV-2 prevalence but there is limited knowledge on
HSV-2 incidence and associated risk factors among fishermen. Methods: Three
hundred fishermen were consented, and evaluated for baseline HSV-2 serology
status and again after 12 months among those negative at baseline. Sexual
behavior and socio-demographic data were collected at enrolment and exit visits
using a structured questionnaire. Baseline HIV serology and Human
papillomavirus (HPV) DNA genotyping were also performed. Multivariate logistic
regression was used to determine independent factors associated with HSV-2
acquisition. Results: Baseline HSV-2 prevalence was 56.3% (95% CI: 50.7 -
62.0). Factors associated with HSV-2 prevalence were, older age (aOR = 1.96;
95% CI: 1.16 - 2.85), history of STI (aOR 2.12; 95% CI: 1.19 - 3.91), infection
with HIV (aOR 2.22; 95% CI: 1.17 - 4.22), ever married (aOR = 3.80; 95% CI:
1.42 - 11.90), most recent sexual act with sex worker/casual partner (OR= 3.56;
95% CI: 1.49 - 8.62) and inconsistent condom use with new sexual partner (aOR =
6.34; 95% CI: 2.24 - 13.04). The HSV-2 incidence was 23.6 (95% CI = 15.4 -
31.8)/100 pyr. Infection with persistent high-risk (HR) HPV (aIRR = 3.35; 95%
CI: 1.21 - 11.37), multiple (≥2)
partners in 12 months prior to study participation (aIRR = 4.77; 95% CI: 1.12 -
11.38), inconsistent condom use with new partner (aIRR =2.53; 95% CI: 1.12 -
7.38) and most recent sexual act with sex worker/casual partner (OR = 3.03; 95%
CI: 1.17 - 8.58) were independent risk factors for HSV-2 acquisition.
Conclusion: The incidence of HSV-2 is very high among fishermen. It is
associated with persistent HR HPV infection and high-risk sexual behavior.
Intervention strategies targeting these men with high risk sexual behavior are
urgently needed to stop new HSV-2 acquisition and subsequently prevent HIV
infection.