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Bai, Y.Q., Yamamoto, H., Akiyama, Y., Tanaka, H., Takizawa, T., Koike, M., Kenji Yagi, O., Saitoh, K., Takeshita, K., Iwai, T. and Yuasa, Y. (2002) Ectopic Expression of Homeodomain Protein CDX2 in Intestinal Metaplasia and Carcinomas of the Stomach. Cancer Letters, 176, 47-55.
http://dx.doi.org/10.1016/S0304-3835(01)00753-4

has been cited by the following article:

• TITLE: CDX2 Overexpression in Barrett’s Esophagus and Esophageal Adenocarcinoma

  AUTHORS: Leandro Almeida Streher, Vinicius Campos, Guilherme da Silva Mazzini, Marcelo Binato, Luise Meurer, Maria Isabel Edelweiss, Richard Ricachenevsky Gurski

  KEYWORDS: CDX2, Barrett’s Esophagus, Intestinal Metaplasia, Esophageal Adenocarcinoma, Immunohistochemistry

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.7, June 3, 2014

  ABSTRACT: Background: Patients with Barrett’s esophagus have an increased risk of developing esophageal adenocarcinoma. Our purpose was to determine CDX2 expression in esophageal mucosa and establish a correlation between this marker and the progression of disease. Methods: We analyzed biopsies and surgical specimens from 150 patients who were divided into five groups according to histopathological diagnosis: G1, normal mucosa (n = 29); G2, esophagitis (n = 19); G3, columnar epithelium without intestinal metaplasia (n = 26); G4, Barrett’s esophagus (n = 32), and G5, adenocarcinoma (n = 44). Immuno-histochemical determination of CDX2 expression was considered positive in the presence of nuclear staining. Results: No CDX2 expression was detected in the G1 or G3 groups; 5% of G2, 62.5% of G4 and 70.5% of G5 patients were CDX2 positive. There was a statistically significant difference between the G4 and G5 groups compared to the G1, G2 and G3 (p