TITLE:
Entropy Approach to the Study of Biological Activity of Chemical Compounds. The Other Side of Radioprotectors
AUTHORS:
Vladimir K. Mukhomorov
KEYWORDS:
Radioprotector, Carcinogen, Information Function, Quasi-valence number
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.1 No.1,
May
19,
2011
ABSTRACT: An attempt made to construct a model of relationship of the radioprotective and carcinogenic properties of biologically active compounds with their electron and information factors. We discovered a simple quantitative structure – activity relationships between the radioprotective effectiveness of chemicals and their molecular structure. It is established that carcinogenic properties of chemical compounds and effective radioprotectors are overlapping with each other. Within the framework of an information approach a systemic factor is proposed for distinguish highly radio protective agents among a series of drug. It was shown that the correlation obtained relating the structure of the compounds of the radio protective effect may be applied to studies of the mechanism of action of the preparations and for the purposeful synthesis of new chemicals.