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Mortimer, C., Wells, G., Crochard, J.P., Stone, E.L., Bradshaw, T.D., Stevens, M.F.G. and Westwell, A.D. (2005) Antitumor Benzothiazoles. 26.1 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines. Journal of Medicinal Chemistry, 49, 179-185.

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• TITLE: The Genus Melodinus (Apocynaceae): Chemical and Pharmacological Perspectives

  AUTHORS: Yao Lu, T. J. Khoo, C. Wiart

  KEYWORDS: Melodinus, Apocynaceae, Ethnopharmacology, Anti-Cancer

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.5, May 30, 2014

  ABSTRACT: The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, hernia, infantile malnutrition, dyspepsia and testitis. Over 100 alkaloids together with flavonoids, lignans, steroids, terpenoids and coumarins have been identified in the genus, and many of these have been evaluated for biological activity. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.