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Bryne, J.C., Valen, E., Tang, M.H., Marstrand, T., Winther, O., da Piedade, I., Krogh, A., Lenhard, B. and Sandelin, A. (2008) JASPAR, the Open Access Database of Transcription Factor-Binding Profiles: New Content and Tools in the 2008 Update. Nucleic Acids Research, 36, D102-D106.

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• TITLE: TBXA2R rSNPs, Transcriptional Factor Binding Sites and Asthma in Asians

  AUTHORS: Norman E. Buroker

  KEYWORDS: TBXA2R, rSNPs, TFBS, Asthma

  JOURNAL NAME: Open Journal of Pediatrics, Vol.4 No.2, May 30, 2014

  ABSTRACT: Four regulatory single nucleotide polymorphisms (rSNPs) (rs2238631, rs2238632, rs2238633 and rs2238634) in intron one, two rSNPs (rs1131882 and rs4523) in exon 3 and one rSNP (rs5756) in the 3’UTR of the thromboxane A2 receptor (TBXA2R) gene have been associated with childhood-onset asthma in Asians. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs) to attach resulting in changes in transcriptional factor binding sites (TFBS). These TFBS changes are examined with respect to asthma which has been found to be significantly associated with the rSNPs.