Article citationsMore>>

Craft, S., Baker, L.D., Montine, T.J., Minoshima, S., Watson, G.S., Claxton, A., Arbuckle, M., Callaghan, M., Tsai, E., Plymate, S.R., Green, P.S., Leverenz, J., Cross, D. and Gerton, B. (2012) Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial. JAMA Neurology, 69, 29-38.
http://dx.doi.org/10.1001/archneurol.2011.233

has been cited by the following article:

• TITLE: Insulin Resistance and Cognitive Functions in a Sample of Prefrail, Frail and Non-Frail Elderly

  AUTHORS: Moatassem S. Amer, Mohamed S. Khater, Nermien N. Adly, Mohamed O. El Maraghy

  KEYWORDS: Insulin, Insulin Resistance, Cognition, Elderly, Frailty

  JOURNAL NAME: Advances in Aging Research, Vol.3 No.2, May 29, 2014

  ABSTRACT: Aim: To study the association between Insulin Resistance (IR) and Glycosylated hemoglobin (HbA1c) and cognition in frail, pre-frail and non-frail elderly. Method: A case control study was conducted on 85 subjects: 60 cases (37 frail and 23 pre-frail subjects) and 25 controls. All subjects underwent comprehensive geriatric assessment including a battery of cognitive tests. Laboratory data included Serum insulin levels, Fasting Blood Sugar, Insulin like Growth Factor-1, C-Reactive Protein (CRP) and HbA1c. Results: Among the pre-frail subjects, Homeostasis Model of Assessment-Insulin resistance (HOMA-IR) and insulin level were positively correlated with Digit Span Backward (DSB) (p = 0.012 and 0.045 respectively). HbA1c was positively correlated with Contrast Programming (CP) (p = 0.01). Controls showed a positive correlation between HOMA-IR and CP, DSB and Mini-Mental Status Examination (P = 0.009, 0.03 and 0.002 respectively). There was no significant correlation in the frail group. Conclusion: In the studied sample, higher insulin, HbA1c, and IR were associated with better cognitive functions in prefrail elderly, and were not associated with worse cognition in frail elderly.