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Wilke, H., Cutsem, E.V., Oh, S.C., Bodoky, G., Shimada, Y., et al. (2014) RAINBOW: A Global, Phase III, Randomized, Double-Blind Study of Ramucirumab plus Paclitaxel versus Placebo plus Paclitaxel in the Treatment of Metastatic Gastroesophageal Junction (GEJ) and Gastric Adenocarcinoma Following Disease Progression on First-Line Platinum- and Fluoropyrimidine-Containing Combination Therapy Rainbow IMCL CP12-0922 (I4T-IE-JVBE). 2014 ASCO Annual Meeting.

has been cited by the following article:

• TITLE: Immunotherapy for Gastrointestinal Malignancies

  AUTHORS: Diwakar Davar, Weijing Sun

  KEYWORDS: Colorectal Carcinoma, Gastric Carcinoma, Pancreatic Carcinoma, Hepatocellular Carcinoma, Gallbladder and Biliary Duct Carcinoma, Advanced, Metastatic, Immunotherapy, Vaccine, Monoclonal Antibody

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.6, May 29, 2014

  ABSTRACT: Gastrointestinal (GI) malignancies (esophageal, gastric, pancreatic, intra- and extra-biliary ductal, hepatocellular, and colorectal cancers) are an important cause of cancer incidence and mortality in the US and globally. GI cancers account for 15.4% and 23.8% of incident cancers and cancer-related deaths respectively in the US alone. Although earlier diagnosis and treatment advances have improved outcomes for some GI malignancies, the need for improved therapies in all disease phases (adjuvant, neoadjuvant and advanced) is paramount. Utilization of monoclonal antibodies targeting against vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) has shown the success in selected colorectal carcinoma patients. More investigations of immunotherapy are on going in the treatment of GI malignances with different mechanisms and methods. In this article, we review data for established and evolving immunotherapy-related treatment options in GI malignancies.