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Van Rossum, L.G.M., Van Rijn, A.F., Laheij, R.J., Van Oijen, M.G., Fockens, P., Van Krieken, H.H., Verbeekx, A.L., Jansen, J.B. and Dekkerx, E. (2008) Radom Comparison of Guaiac and Immunochemical Fecal Occult Blood Tests for Colorectal Cancer in a Screening Population. Gastroenterology, 135, 82-90.
http://dx.doi.org/10.1053/j.gastro.2008.03.040

has been cited by the following article:

• TITLE: Colorectal Cancer Screening in a Spanish Town: Evaluation of Colonoscopy Preparation, Sedation by the Endoscopist and Screening Results

  AUTHORS: Rebeca Higuera Álvarez, Raquel González Monasterio, Fidencio Bao Pérez, Pablo Ruiz Eguiluz

  KEYWORDS: Colorectal Cancer Screening Preparation Sedation

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.4 No.5, May 22, 2014

  ABSTRACT: Objective: The aim of this study is to evaluate the colonic cleansing preparation and colorectal cancer screening results in Sestao (Bilbao); and to verify the safety of endoscopist-controlled sedation. Materials and methods: A retrospective observational study of colorectal cancer screening using the immunological faecal occult blood test in a medium-risk population in this region, with colonoscopy being performed in the event of a positive result. The colonic cleansing preparation was administered in split doses; the second dose was administered 4 hours prior to colonoscopy. The quality of the preparation and lesion detection were evaluated. Sedation-related complications were analyzed. Results: Participation was high (4342 of 6896 people invited, 62.99%), with 309 subjects (7.12%) presenting a positive immunological faecal occult blood test. A high percentage of the 284 colonoscopies had optimal preparation: 276 (97.18%) had an adequate preparation. A total of 22 (7.91%) sedation-related complications were detected: only one (0.36%) was serious. A total of 140 high-risk adenomas were removed (47.13%) and 24 carcinomas were diagnosed (8.08%). Both these percentages are high. Conclusions: Split doses of colonoscopy preparation and reduction of the time interval between the second dose and the colonoscopy result in a high percentage of adequate preparation and lesion detection. Sedation by trained endoscopists is safe and effective. An immunological faecal occult blood test-based screening program is feasible and allows malignant and precancerous lesions to be efficiently detected and treated.