TITLE:
A Clinic-Epidemilogical Study of Cases of Locally Advanced Non Small Cell Lung Cancer (NSCLC) That Received Radiotherapy at NCI Cairo in the Period from 2001-2010
AUTHORS:
Mohamed Lotayef, Azza Taher, Hanna Attia, Azza Nasr, Hisham El Hossieny, Mohammed Mahmoud, Noha Essam
KEYWORDS:
Non Small Cell Lung Cancer, Concomitant Chemo-Radiotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.6,
May
16,
2014
ABSTRACT: Purpose: This work was to
study the clinic-epidemiological characteristics of patients with locally
advanced NCSLC and to analyze their prognostic factors and also the results of
different treatment modalities for local control and their effect on overall
survival (OAS). Materials and Methods: This is a retrospective study including
121 patients with primary locally advanced NSCLC diagnosed between 2001 and
2010 at the radiotherapy department , National Cancer Institute, Cairo
University, Egypt. Results: The study showed significant correlation between
the tumor size 60, moderately differentiated tumors G2
and treatment outcomes; better locoregional control and better survival rates.
On the opposite side poorly differentiated tumors G3, tumor size > 7 cm had
the worst locoregional control and survival rates. The study also showed
significant statistical correlation between treatment modality, locoregional
control and survival rates. Patients who were treated by either concommitent
chemo-radiotherapy or sequential chemo-radiotherapy had better local control
compared to other patients who were treated by radical radiotherapy, and they
also had the best survival rates among all the other treatment groups. The
average 6 months OAS rates for all studied patients were 60.3% while 12 months
survival rates were 38.8%. The median OAS was 7 months. Conclusions: From the
present study, we concluded that concomitant chemo-radiotherapy is the
treatment of choice for locally advanced non small cell lung cancer; also we
concluded that better performance status and higher hemoglobin levels have
better treatment outcome in these cases.