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Black, P.C., Brown, G.A., Inamoto, T., Shrader, M., Arora, A., Radtke, A.O.S., Adam, L., Theodorescu, D., Wu, X., Munsell, M.F., Eli, M.B., McConkey, D.J. and Dinney, C.P.N. (2008) Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells. Clinical Cancer Research, 14, 1478-1486.
http://dx.doi.org/10.1158/1078-0432.CCR-07-1593

has been cited by the following article:

• TITLE: Effects of 4-(3-Chloro-Benzyl)-6,7-Dimethoxy-Quinazoline on Kinetics of P120-Catenin and Periplakin in Human Buccal Mucosa Squamous Carcinoma Cell Line

  AUTHORS: Isao Tamura, Aiko Kamada, Seiji Goda, Yoshihiro Yoshikawa, Eisuke Domae, Takashi Ikeo

  KEYWORDS: 4-(3-Chloro-Benzyl)-6, 7-Dimethoxy-Quinazoline, Human Buccal Mucosa Squamous Cancer Cell Line, P120-Catenin, Periplakin

  JOURNAL NAME: Open Journal of Stomatology, Vol.4 No.5, May 15, 2014

  ABSTRACT: In order to detect molecular markers for the epidermal growth factor inhibitor 4-(3-chloro-benzyl)- 6,7-dimethoxy-quinazoline (tyrphostin), we investigated the kinetics of p120-catenin and periplakin in the human buccal mucosa squamous cancer cell line BICR 10 treated with 3 nM tyrphostin. Growth of BICR 10 cells was inhibited by treatment with tyrphostin. Although changes were not observed in the expression of EGFR and p120-catenin, expression of Akt, Src and periplakin in BICR 10 treated with 3 nM tyrphostin tended to decrease. In addition, phosphorylation of EGFR, Akt and Src was inhibited by treatment with tyrphostin. On immunocytochemical staining, immunoreactions with phosphorylated EGFR, phosphorylated Akt and phosphorylated p120-catenin were weak in BICR 10 treated with tyrphostin. There was a slight immunocy to chemical reaction to periplakin in BICR 10 cells induced by tyrphostin. In conclusion, the decrease in phosphorylation in EGFR and p120-catenin by tyrphostin, following the decrease in Src or Akt phosphorylation, may inhibit expression of several growth factors associated with the proliferation and migration of cancer cells.