TITLE:
The Nephrotoxic Impact of Oseltamivir in Male Albino Rats after Repeated Exposure
AUTHORS:
Falah Muosa Kadhim Al-Rekabi
KEYWORDS:
Olseltamivir, Nephrotoxic, Albino Rats, Repeated Exposure
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.5,
May
13,
2014
ABSTRACT: The effects of
oseltamivir administration, effectively against influenza viruses A and B, on
some selected parameters of rat kidney function were investigated to evaluate
its possible nephrotoxic effects. Eighteen (18) albino male Wistar rats with
body weights ranging from 150 - 190 g were divided into three groups, the
first group (T1) was treated orally with 1 mg/kg BW as a therapeutic dose of oseltamivir
for 7 consecutive days. The second group (T2) was treated with the same dose
for six weeks, while the control group was dosed with distilled water. The
results revealed a significant increase (P