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Sweeny, D.J., Lynch, G, Bidgood, A.M., Lew, W., Wang, K.Y. and Cundy, K.C. (2000) Metabolism of the Rat Influenza Neuraminidase Inhibitor Prodrug Oseltamivir in the Rat. Drug Metabolism and Disposition, 7, 737-774.

has been cited by the following article:

• TITLE: The Nephrotoxic Impact of Oseltamivir in Male Albino Rats after Repeated Exposure

  AUTHORS: Falah Muosa Kadhim Al-Rekabi

  KEYWORDS: Olseltamivir, Nephrotoxic, Albino Rats, Repeated Exposure

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.5, May 13, 2014

  ABSTRACT: The effects of oseltamivir administration, effectively against influenza viruses A and B, on some selected parameters of rat kidney function were investigated to evaluate its possible nephrotoxic effects. Eighteen (18) albino male Wistar rats with body weights ranging from 150 - 190 g were divided into three groups, the first group (T1) was treated orally with 1 mg/kg BW as a therapeutic dose of oseltamivir for 7 consecutive days. The second group (T2) was treated with the same dose for six weeks, while the control group was dosed with distilled water. The results revealed a significant increase (P