TITLE:
Low-Dose Involved-Field Radiotherapy in Relapsed Low-Grade Non-Hodgkin's Lymphoma in Elderly Patients (Mansoura University Experience)
AUTHORS:
Hend Ahmed El-Hadaad, Hanan Ahmed Wahba, Ibrahim Awad
KEYWORDS:
Low-Grade Lymphoma, Relapsed Non-Hodgkin’s Lymphoma, Low-Dose Radiotherapy in Lymphoma
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.6,
May
8,
2014
ABSTRACT: Purpose: To assess the
response rate, duration of response and prognostic factors affecting response
after low-dose involved-field radiotherapy in patients with relapsed low-grade
B-cell non-Hodgkin lymphoma. Patients and Methods: Forty-four patients were
included. Patients were treated with a total dose of 4 Gy (2 × 2 Gy) using 6 -
15 Mv photon or electron beam. Results: most patients were above age of 60
years (59%) with male predominance. Follicular lymphoma was the most common
pathological type; bulky disease (>5 cm) was presented in 61.4%. Patients
who received only 2 regimens were 63.7% and 31.8% had >2 involved sites. No
treatment related toxicity was observed. The overall response rate was 88.7%;
complete response was reached in 59.1% and stable disease in 6.8%, progressive
disease in 4.5%. Median time to local progression was 33 months (95% CI 23.70 -
42.29); 2-year local progression free survival was 78%. Response rate was found
to be dependent on age, number of involved sites and lymph node size but
independent on sex, pathological type, number of prior regimens, LDH level and
time since diagnosis. Conclusion: Short-course-low dose palliative radiotherapy
(2 × 2 Gy) affords an attractive option for treatment of relapsed low-grade
non-Hodgkin’s lymphoma due to high response rates. However, these results had
to be confirmed in a larger number of patients.