TITLE:
Homocystiene and C-Reactive Protein in Detection of Frailty
AUTHORS:
Moatassem S. Amer, Tamer M. Farid, Ekrami E. Abd El-Rahman, Deena M. EL-Maleh, Omar H. Omar, Randa A. Mabrouk
KEYWORDS:
Frailty, CRP, Homocystiene
JOURNAL NAME:
Advances in Aging Research,
Vol.3 No.2,
May
8,
2014
ABSTRACT: Background and Aim of the Work: Frailty is a
state of reduced physiological reserve and is associated with increased
susceptibility to disability. It is associated with a high morbidity and
mortality. The aim of this work is to assess the association between the levels
of homocystiene and C-reactive protein and frailty and to examine the ability
of homocystiene as a new marker to detect frailty. Subjects and Methods: A
total number of 104 elderly subjects (above 60 years old) were included in
this study and they were subjected to history, examination, comprehensive
geriatric assessment, and laboratory investigations including: C-reactive
protein (CRP) and Homocystiene (Hcy). The patients were divided into frail and
non-frail groups using Fried’s criteria as applied by Avila-Funes et al.,
2008 and each group included 52 patients. Results: There was no significant
difference between the two groups as regards age gender or smoking habits. But
there were higher levels of CRP (>10 mg/dl) and homocystiene (>12 mmol/l)
among frail cases and by comparing both homocystiene was more sensitive in detection
of frailty. Conclusion: Frailty was associated with eleveted homocystiene and
CRP and homocystiene is more specific than CRP in detection of frailty.