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Liu, F., Worthy, K.M., Lakshman, B., Alessio, G., Bottaro, D.P., Fisher, R.J. and Burke, T.R. (2007) Utilization of Achiral Alkenyl Amines for the Preparation of High Affinity Grb2 SH2 Domain-Binding Macrocycles by Ring-Closing Metathesis. Organic & Biomolecular Chemistry, 5, 367-372.
http://dx.doi.org/10.1039/b611887a

has been cited by the following article:

• TITLE: New One-Pot Methods for Preparation of Cyclohexanecarbonitrile—Green Chemistry Metrics Evaluation for One-Pot and Similar Multi-Step Syntheses

  AUTHORS: Jan Simbera, Richard Sevcik, Pavel Pazdera

  KEYWORDS: Cyclohexanecarbonitrile, One-Pot Synthesis, EcoScale, EATOS, SIS

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.4 No.2, May 7, 2014

  ABSTRACT: Three new multi-step one-pot processes for high-yielding cyclohexanecarbonitrile synthesis starting from cyclohexanone were developed for industrial application. In contrast to the current synthetic process, all of the processes described were designed to proceed completely in methanol as a uniform solvent and the key oxidation step can be realized either as stoichiometric or catalytic. Atom efficiency of processes is relatively advanced with high regioselectivity, reaction by-products are either from environmental pool—carbon dioxide and nitrogen—or they can be reused—sodium chloride. Solvent—methanol—and other auxiliaries—cyclohexane, copper catalyst—can be reused after recycling as well. EcoScale for all three designed processes was evaluated and compared with current synthesis described in the past. Green chemistry metrics, including newly introduced evaluative tool—Sustainability Index of the Synthesis (SIS), were applied to evaluate design of described one-pot syntheses.