TITLE:
Prediction of Transformation of Acute Disseminated Encephalomyelitis into Multiple Sclerosis
AUTHORS:
Olena Myalovitska, Iryna Lobanova, Tetyana Kobys
KEYWORDS:
Acute Disseminated Encephalomyelitis, Multiple Sclerosis, Prediction, Kaplan-Meyer Method
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.8,
April
17,
2014
ABSTRACT: Prediction
of transformation of acute disseminated encephalomyelitis (ADEM) into multiple
sclerosis is of great clinical importance, as it enables timely determination of
the tactics for treatment of a patient as well as volume of respective
therapeutic interventions.This work is aimed at
ascertainingthe prognostic factors that determine the risk of
transformation of acute disseminatedencephalomyelitis
into multiple sclerosis. We have examined 101 patients with the diagnosis ADEM,
namely: 28 men and 73 women in the age from 17 up to 53 years (average value31.7 ± 1.01years).
To ascertain the prognostic meaning of clinic-paraclinic indices corresponding
to patients with ADEM, we estimated the cumulative part of absence of relapses
in the group of patients by using the Kaplan-Meyer method with estimating the
Fisher criterion and using the most important clinic-paraclinic data. Development
of transformation of ADEM into multiple sclerosis is reliably related to the
following prognostic signs: degree of disability in accord with the EDSS scale
and sizes of demyelination focuses determined using MRT. Criteria for congenial
prediction in disease development with delayed appearance of transformation of
ADEM into multiple sclerosis are as follows: slight degree (in EDSS scale) of
disability and large sizes of demyelination focuses (MRT data).Our analysis of the main clinic-paraclinic indexes
obtained using the Kaplan-Meyer method indicates reliability of results and
enables us to find a number of important prognostic criteria for development of
transformation of ADEM into multiple sclerosis.