TITLE:
Participation of Morphofunctional Zones in Aging Processes
AUTHORS:
T. M. Yavisheva, S. D. Shcherbakov
KEYWORDS:
Morphofunctional Zones, Hypothalamus, RhoA Protein, Src Kinase, Aging
JOURNAL NAME:
Advances in Aging Research,
Vol.3 No.2,
April
29,
2014
ABSTRACT: There are morphofunctional zones in organism tissues, where proliferation
and differentiation processes occur. Daughter cells are differentiated in the
electric field excited by 12 mother and daughter cell pairs, which turned out
at cambial cell division. With aging, the cambial cell number is reduced to 7, which
is close to threshold level (6 cells), at which the differentiation of daughter
cells is absent. The depression of cambial cell number with aging is connected
with the work of another morphofunctional zone—the hypothalamus, which is the major center of vegetative regulation and
initially has very high RhoA activity, which has been established in
embryogenesis. Estrogens, influencing over the hypothalamus and activating Src
kinase in its nuclei, reduce level of RhoA activity, including SCN, responsible
for many biorhythms of an organism. As a result, the hyperestrogenemia and
therefore a connective tissue at first occur. Then there happens a hypoestrogenemia
that leads to sharp falling of proliferative activity of cells, causing the
depression of cambial cell number and possibility of a malignant tumor
development. Along with this, there are the deep lesions of hormone regulation,
leading to some lethal diseases. Thus, the RhoA increasing in hypothalamus and
especially in SCN circadian rhythm can counteract the Src kinase intensifying
and prevent the processes connected with this.