TITLE:
Incorporation of Carboplatin in Microporous Granular Calcium Phosphate Biphasic Matrix
AUTHORS:
Cleomar Copatti, N. H. A. Camargo, E. Gemelli
KEYWORDS:
Elaboration; Biphasic; Biomaterial; Microporosity; Drug
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.2 No.2,
April
29,
2014
ABSTRACT: The HA/β-TCP biphasic bioceramics stand out
on researches in different areas of biomedical applications. These bioceramics
with microporous microstructures also stand out in biomedical applications on
controlled drug release. This study aimed at the synthesis of the biphasic HA/β-TCP
powder, and at the elaboration and characterization of the microporous biphasic
HA/β-TCP granular biomaterial. The microporous granular material was elaborated
through the process of ceramic powder sieving (200 μm °C/2 h,
providing the microporous biphasic granular biomaterial. The drug loading in
the biomaterial was performed through the high vacuum method. The results here
presented are related to the synthesis method and elaboration of the biphasic
biomaterial. The results obtained from the drug loading through the high vacuum
method conducted the incorporation of the drug onto the surface and into the
microporous granular biomaterial.