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Park, J.H., Wasilewski, C.E., Almodovar, N., Olivares-Navarrete, R., Boyan, B.D., Tannenbaum, R. and Schwartz, Z. (2012) The Responses to Surface Wettability Gradients Induced by Chitosan Nanofilms on Microtextured Titanium Mediated by Specific Integrin Receptors. Biomaterials, 33, 7386-7393. http://dx.doi.org/10.1016/j.biomaterials.2012.06.066

has been cited by the following article:

• TITLE: In Vivo Evaluation of Titanium Implants Bioactivated by a Modified Kokubo’s Treatment

  AUTHORS: Jailson de Jesus, Enori Gemelli, Fábio Nery, Nelson H. A. Camargo

  KEYWORDS: Titanium; Thermochemical Treatment; Wettability; In Vivo Test

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.2 No.2, April 29, 2014

  ABSTRACT: In this study a modified Kokubo’s treatment (MKT) was used to bioactivate titanium implants. Titanium surfaces were alumina-blasted and etched in HCl/H2SO4 solution followed by treatment in autoclave at 120°C for 1, 3, 5 hour periods with chemical solutions containing 1, 2 and 3 M of NaOH. The materials were characterized by surface angle measurements, roughness, field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), and in vivo tests. Statistical analysis by polynomial regression showed that solutions within 2.2 and 2.8 M NaOH lead to surface contact angles close to zero degree after 1 h of treatment. XPS analysis carried out on a sample treated 1 h in 2.2 M NaOH indicated the presence of a titanate film. This solution was selected to treat titanium implants for in vivo tests. These tests were performed on sheep in three types of separating surfaces: machined group (standard), SLA group (A) and MKT group (B) divided into two time intervals of 3 and 6 weeks. The samples in group B displayed better results compared to group A only after 6 weeks in terms of counter torque and bone implant contact (BIC).