TITLE:
The Relationship between Nigerian Bonnylight Crude Oil-Induced Hypoglycaemia and Endogenous Serum Insulin Concentration in Male Wistar Rats: The Role of Antioxidant Vitamins C and E
AUTHORS:
S. O. Ita, E. O. Aluko, T. H. Olubobokun, U. A. Okon, A. B. Antai, E. E. Osim
KEYWORDS:
Nigerian Bonny Light Crude Oil; Hypoglycaemia; Serum Insulin Concentration; Antioxidant Vitamins
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.4 No.2,
April
28,
2014
ABSTRACT: The relationship
between Nigerian Bonny Light crude oil (NBLCO) induced
hypoglycaemia and endogenous serum insulin concentration; the role of
antioxidant vitamin C or E supplementation was the focus of this study. Forty
adult male Wistar rats were randomly divided into group I, which served as the
control, group II, which was oral gavaged 6 ml/kg of NBLCO, groups III and IV, which
were in addition to 6 ml/kg of NBLCO supplemented with 9 ml/kg and 1 mg/kg of
vitamin E or C, respectively for 28 days. Results showed that NBLCO
significantly (p p p p been demonstrated in this study that direct
oral ingestion of crude oil (NBLCO) could reduce food intake, body weight and
cause hypoglycemia; the hypoglycemia may not be a function of serum insulin
concentration. Interestingly, the hazardous effects of NBLCO could be
ameliorated with antioxidant vitamin C or E supplementation.