TITLE:
Determinants of Malignant Transformation in Fibrocystic Disease of Breast
AUTHORS:
Ketan Vagholkar
KEYWORDS:
Fibrocystic Disease Breast Carcinoma
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.3 No.2,
April
28,
2014
ABSTRACT: Background: Fibrocystic disease of the
breast in one of the commonest diseases in
women above 30 years of age. The assumption of it being innocuous and benign is
questionable with increased incidence of malignancies developing in these
women. Introduction: Understanding the pathophysiology of fibrocystic disease
is essential for identifying determinants of malignant change. Case Report: A
case of carcinoma of breast developing in a longstanding and recurrent
fibrocystic disease is reported. Discussion: The pathological changes including
the influence of hormones on the natural history of the disease arediscussed to identify the
determinants of malignant transformation. Conclusion: Breast cyst fluid,
patterns of cellular lining of the cysts, multiplicity, recurrence and patterns
of cellular morphology are important determinants of malignant change.