TITLE:
Obesity, Diabetes Mellitus and Vascular Disease: A Complex Relationship with Prostate Cancer
AUTHORS:
Simona Di Francesco, Raffaele L. Tenaglia
KEYWORDS:
Prostate Cancer, Obesity, Diabetes Mellitus, Vascular Disease
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.5,
April
23,
2014
ABSTRACT: Background: Obesity, type
II Diabetes mellitus (DMII) and vascular damage could be implicated in prostate
cancer (PCa) nevertheless no clear results has been reached. The aim of the research
was to investigate the association of these alterations with PCa at initial
diagnosis, without the influence of hormone therapy or chemotherapy. Methods:
Retrospective analysis of 400 patients undergoing prostate biopsy at our
institution between 2005 and 2012 was conducted. We examined associations of
obesity, DMII and vascular damage in 200 patients with PCa diagnosis versus 200
age-matched controls. Men with history of hormone therapy or chemotherapy,
prostate or bladder surgery were excluded. Results: Obesity was significantly
associated (OR 2.10, p