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Sabat, R., Grutz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K. and Geginat, J. (2010) Biology of Interleukin-10. Cytokine & Growth Factor Reviews, 21, 331-344. http://dx.doi.org/10.1016/j.cytogfr. 2010.09.002

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• TITLE: Immune Response Indicated by Expressing of IL-2 and IL-10 in Cervical Cancer

  AUTHORS: Adi Prayitno, Okid Parama Astirin, Suhartono Taat Putra

  KEYWORDS: IL-2, IL-10, Immune Response, Cancer

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.5, April 23, 2014

  ABSTRACT: Introduction: Interleukin-2 (IL-2) is multiple which functions during an inflammatory response. Inflammation is a critical component of cancer progression. IL-10 is the most important cytokine with anti-inflammatory properties. Cancer patients typically show depression of both cellular and humoral immune functions. Aims: The objective of this experiment is to know the expression of IL-2 and IL-10 in cervical cancer. Method: Paraffin block of the tissues frozen section cervical cancer was cut in sharp and cleaned cryotome and place in glass plate that covered with poly-elysine. The immunohistochemistry stains were done with monoclonal antibody anti IL-2 and IL-10 with TSA-indirect method. The collected data were analyzed with T Test (SPSS for window 15). Result: In this study the expression of IL-2 (35.9% = moderate) is less than the expression of IL-10 (45.3% = moderate). From T Test analysis of p