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Shen-Orr, S.S., Goldberger, O., Garten, Y., Rosenberg-Hasson, Y., Lovelace, P.A., Hirschberg, D.L., Altman, R.B., Davis, M.M. and Butte, A.J. (2009) Towards a Cytokine-Cell Interaction Knowledgebase of the Adaptive Immune System. Pacific Symposium on Biocomputing, 2009, 439-450.

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• TITLE: Immune Response Indicated by Expressing of IL-2 and IL-10 in Cervical Cancer

  AUTHORS: Adi Prayitno, Okid Parama Astirin, Suhartono Taat Putra

  KEYWORDS: IL-2, IL-10, Immune Response, Cancer

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.5, April 23, 2014

  ABSTRACT: Introduction: Interleukin-2 (IL-2) is multiple which functions during an inflammatory response. Inflammation is a critical component of cancer progression. IL-10 is the most important cytokine with anti-inflammatory properties. Cancer patients typically show depression of both cellular and humoral immune functions. Aims: The objective of this experiment is to know the expression of IL-2 and IL-10 in cervical cancer. Method: Paraffin block of the tissues frozen section cervical cancer was cut in sharp and cleaned cryotome and place in glass plate that covered with poly-elysine. The immunohistochemistry stains were done with monoclonal antibody anti IL-2 and IL-10 with TSA-indirect method. The collected data were analyzed with T Test (SPSS for window 15). Result: In this study the expression of IL-2 (35.9% = moderate) is less than the expression of IL-10 (45.3% = moderate). From T Test analysis of p