TITLE:
Immune Response Indicated by Expressing of IL-2 and IL-10 in Cervical Cancer
AUTHORS:
Adi Prayitno, Okid Parama Astirin, Suhartono Taat Putra
KEYWORDS:
IL-2, IL-10, Immune Response, Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.5,
April
23,
2014
ABSTRACT: Introduction:
Interleukin-2 (IL-2) is multiple which functions during an inflammatory
response. Inflammation is a critical component of cancer progression. IL-10 is
the most important cytokine with anti-inflammatory properties. Cancer patients
typically show depression of both cellular and humoral immune functions. Aims:
The objective of this experiment is to know the expression of IL-2 and IL-10 in
cervical cancer. Method: Paraffin block of the tissues frozen section cervical
cancer was cut in sharp and cleaned cryotome and place in glass plate that
covered with poly-elysine. The immunohistochemistry stains were done with
monoclonal antibody anti IL-2 and IL-10 with TSA-indirect method. The collected data were
analyzed with T Test (SPSS for window 15). Result: In this study the expression
of IL-2 (35.9% = moderate) is less than the expression of IL-10 (45.3% =
moderate). From T Test analysis of p