TITLE:
Chondrosarcoma of the Hand: A Literature Review
AUTHORS:
Daniele Stomeo, Antonio Tulli, Antonio Ziranu, Federica Mariotti, Giulio Maccauro
KEYWORDS:
Chondrosarcoma, Chondrogenic Tumour, Hand, Finger, Digit, Treatment, Surgery, VEGF
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.4,
April
22,
2014
ABSTRACT: Chondrosarcoma (CS) is a malignant neoplasm of mesenchymal origin characterized by the formation of cartilaginous matrix by neoplastic cells. It is very variable in presentation, clinical, genetic and anatomo-pathological features. CS is more often found in the pelvis and the proximal long bones (femur, humerus). Localization to the small bones of the hand is very rare and it represents a diagnostic and therapeutic challenge. CSs are malignancies resistant to both radiation and chemotherapy . Surgical treatment is the only mean available. As opposed to CSs located elsewhere, CS of the hand is characterized by local recurrence and very low metastatic potential. In order to definitely set a diagnosis of chondrosarcoma in this region, comparison of histological and radiological findings is paramount. The principle goal of surgery shall be minimizing functional impairment. This provides the rationale for performing curettage, local adjuvant therapy and bone grafting in low-grade lesions.