TITLE:
Proliferative Brenner Tumor with Borderline Mucinous Cystadenocarcinoma of the Ovary in a 75-Year-Old Woman
AUTHORS:
Kenji Niwa, Hiroshi Makino, Yoshio Yamaguchi, Sakae Mori, Nozomi Narikawa, Takuji Tanaka
KEYWORDS:
Proliferative Brenner Tumor, Ovary, Pseudo-Meigs' Syndrome, Transitional Cell, Cytology, Immunohistochemistry
JOURNAL NAME:
Open Journal of Pathology,
Vol.4 No.2,
April
22,
2014
ABSTRACT: We report
here an extremely rare case of proliferative Brenner tumor with borderline
mucinous cystadenocarcinoma of the ovary, metastasizing to the pleura in a
75-year-old woman. Massive pleural effusion were present due to metastasis and pseudo-Meigs’
syndrome. The cytological findings from pleural effusion, ascites and tumor
imprint were similar, suggesting mucus-producing malignant tumors. After receiving
a thoracic drainage for pleural effusion, the patient underwent an exploratory
laparotomy to remove the left-ovarian tumor. Histopathological examination
revealed proliferative Brenner ovarian tumor with borderline mucinous cystadenocarcinoma,
and immunohistochemical examinations for the tumors, even mucus-rich tumor
cells were positive for CK 7 and negative for CK 20, suggesting the tumor
arising from transitional cells, not from mucus-producing ovarian surface
epithelial tumor cells. She underwent four courses of chemotherapy with
paclitaxel and carboplatin. The patient showed no signs of recurrence 16 months
after the surgery.