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Rankin, C.H., Abrams, T., Barry, R.J., Bhatnagar, S., Clayton, D.F., Colombo, J., Coppola, G., Geyer, M.A., Glanzman, D.L., Marsland, S., McSweeney, F.K., Wilson, D.A., Wu, C.-F. and Thompson, R.F. (2009) Habituation Revisited: An Updated and Revised Description of the Behavioral Characteristics of Habituation. Neurobiology of Learning and Memory, 92, 135-138. http://dx.doi.org/10.1016/j.nlm.2008.09.012

has been cited by the following article:

• TITLE: Possibility of “Comet-Like” Transport of Acetylcholine Receptors in Command Helix Neurons in Cellular Analog of Habituation

  AUTHORS: Arkady S. Pivovarov, Galina B. Murzina, Denis A. Makhnovsky, Mariya S. Tret’yakova

  KEYWORDS: CK-548, CK-636, Wiskostatin, Depression of Acetylcholine-Induced Inward Current, Command Neurons, Helix lucorum, Cellular Analog of Habituation

  JOURNAL NAME: World Journal of Neuroscience, Vol.4 No.2, April 22, 2014

  ABSTRACT: The presence of "comet-like" radial transport of acetylcholine receptors by actin microfilaments without the participation of myosin motors in the depression of acetylcholine-induced inward chloric current (ACh-current) in command neurons of defensive behavior of the land snail, Helix lucorum, in a cellular analog of habituation was investigated. For that purpose the effects of CK548, CK-636 (inhibitors of actin-related protein complex Arp2/3, whose activation triggers rapid actin polymerization and the formation of the "comet-like" tail on the actinic filament) and wiskostatin (an N-WASP protein inhibitor, activating Arp2/3) on the depression of ACh-current were studied. The attenuation of ACh-current depression was observed upon the addition of CK548. At the same time, CK-636 and wiskostatin irreversibly strengthened the depression of this current and suppressed its spontaneous recovery. The results of CK-548 action and its mathematical modeling allow suggesting the presence of "comet-like" transport of acetylcholine receptors, initiated by Arp2/3 protein complex in receptor endo and exocytosis in command neurons of Helix lucorum in a cellular analog of habituation. Irreversible inhibition of vital metabolic processes of the neuron by wiskostatin and CK-636, which lead to the decrease in the level of ATP, could have caused irreversible effects of these blockers on current depression.