TITLE:
Efficacy and Safety of Patient-Led Dosage Adjustments of Insulin Glargine: A Preliminary Report of Basal-Supported Oral Therapy for Japanese Type 2 Diabetes Patients
AUTHORS:
Shuhei Nakanishi, Mitsunobu Kubota, Rui Kishimoto
KEYWORDS:
Glargine, Self-Titration, BOT, T2DM, Insulin
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.2,
April
21,
2014
ABSTRACT: To evaluate the clinical
utility for simple patient administered dose adjustment methods of insulin
glargine during outpatient visits compared with a physician managed titration,
changes in HbA1c and total daily dose of insulin were evaluated in 23 patients
by dividing patients into physician-led (PL) group and self-titration (ST)
group who were newly administered glargine basal-supported oral therapy (BOT)
while continuing oral antidiabetic drugs at the discretion of their attending
physician during regular outpatient visits. In the PL group, one month after
initiation of glargine, HbA1c followed a declining trend, although this was not
significant (P = 0.07), and decreased significantly after two and three months
(P