TITLE:
Antinociceptive Effects of Pomegranate (Punica granatum L.) Juice and Seed Extracts on Acute Corneal Pain in Mice
AUTHORS:
Zahra Malek, Shirin Mansoori Dara, Mahsa Hadipour Jahromy
KEYWORDS:
Punica granatum, Morphine, Naloxone, Acute Corneal Pain, Mice
JOURNAL NAME:
World Journal of Neuroscience,
Vol.4 No.2,
April
18,
2014
ABSTRACT: In the present study, the antinociceptive effects of acute (2, 4 and 6 ml/kg) and chronic (1, 2 and 3 ml/kg for 14 days)oral administration ofpomegranate (Punica granatumL.) juice and seedextract with or without morphine and naloxane were
investigatedonhypertonic saline-induced acute corneal pain perception in
mice. The number of eye wipes with a forelimb was counted for a period of 30
seconds as the criterion for pain assessment. Acute oral administration of the
extract(at 6 ml/kg dose, once) and chronic oral administration(at 2 and 3 ml/kg for 14 days each) significantly decreased
the number of eye wipes after subcutaneous injection of morphine (2 mg/kg, sc),
naloxone (2 mg/kg, sc) and normal saline (2 mg/kg, sc) compared with control (p