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Minoli, G., Meucci, G., Bortoli, A., Garripoli, A., Gullotta, R., Leo, P., Pera, A., Prada, A., Rocca, F. and Zambelli, A. (2000) The ASGE Guidelines for the Appropriate Use of Colonoscopy in an Open Access System. Gastrointest Endosc, 52, 39-44.

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• TITLE: Effects of Metoclopramide Orally Disintegrating Tablet in Optimizing Late Outpatient Endoscopy: A Randomized Double-Blind Placebo-Controlled Clinical Trial

  AUTHORS: Patrick P. Basu, Niraj J. Shah, Hemanth Hampole, Nitya Krishnaswamy, Mark M. Aloysius

  KEYWORDS: Metoclopramide; ODT; Endoscopy

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.4 No.4, April 16, 2014

  ABSTRACT: Aims: Metoclopramide has been used as a gastro-kinetic agent but the safety and effects of different preparations of metoclopramide on preparation for outpatient endoscopy are largely unknown. The study aimed to evaluate the (1) Safety of using ODT (orally disintegrating tablet) or TT (traditional tablet) metoclopramide pre-endoscopy in non-fasting patients compared with placebo (2) Impact of ODT or TT metoclopramide on sedation and recovery times compared with placebo. Methods: A double blind randomized placebo-controlled trial with 3 arms; Metoclopramide ODT (n = 43), Metoclopramide TT (n = 43) and Placebo (n = 43). Results: Metoclopramide ODT had fewer adverse events compared with TT or placebo. Recovery time was significantly shorter with use of either metoclopramide versus placebo (P