TITLE:
Analysis of Chicken T Cell-Mediated Responses on Thymus after Immune Stress
AUTHORS:
Zhenhu Jia, Yufang Cao, Yaju Xue, Fangxiang Li, Min Liu, Cai Zhang, Yufei Yang, Jiangyan Duan
KEYWORDS:
T Cells, Chicken Thymus, Immunological Stress
JOURNAL NAME:
Journal of Immune Based Therapies, Vaccines and Antimicrobials,
Vol.3 No.2,
April
14,
2014
ABSTRACT: In order to assess chicken T cell-mediated responses after immune stress, 200 two-week-old chickens were randomly divided into control group(C) and treatment groups (T1 and T2). The live I-type of Newcastle disease vaccine (ND) was taken as the source of immunological stress. The chickens in group (T2) were injected with overdose of live I-type Newcastle disease vaccine. After vaccination, the dynamic changes of CD4+, CD8+T cells on thymus were detected by immunohisto-chemistry. The ultra-structure of T cells on thymus of the chickens in group (T2) was observed by electron microscopic. The result showed: (1) After immune stress, from day 1 to day 5, the number of the CD4+T cells significantly declined and reached the bottom at day 5, but the number of the CD8+T cells increased dramatically and peaked at day 5. (2) After immune stress, from day 1 to day 5, part of T cells of chicken thymus came with apoptotic and pathological changes of putrescence continually. These results underscore: the immune stress can cause transient immune adjustment. These changes for chickens were the self-protection mechanism of immune system to adapt to survival and avoid immune disorder.